Risk Factors for Melanoma by Anatomic Site
The authors analyzed data from 2617 first invasive melanomas (975 controls) from 2 population-based case–control studies in Australia and the UK. They found that the incidence of melanoma was highest on the trunk (35%) and lower limbs (34%) and was lower for the upper extremities (20%) and head and neck sites (11%). Men had a higher frequency of melanoma on the head and neck, whereas women more frequently had disease on the extremities. Melanomas occurred more often on the head and neck than on any other site in patients older than 70 years. Higher density of nevi was associated with higher odds for melanoma of all sites, but a stronger association was seen with many nevi and melanoma on the trunk and extremities. Very fair skin type was associated with melanoma on non-truncal locations.
This study sheds light on the factors that affect the risk of developing melanoma and how they vary based on the anatomic site of the melanoma. These data support the dual-pathway hypothesis, which holds that truncal melanomas are more strongly related to nevi and intermittent sun exposure, while head and neck melanomas are more related to chronic sun exposure.
Source: Caroline K. Crabtree, MD, Practice Update [3/4/21] via Dr. Allen Jacobs
From: Nicholas A. Ciotola, DPM
What I have found problematic in most studies on the role of various orthotic devices in plantar fasciopathy is that they all treat this disease like it is a homogeneous entity. Future investigations would be more robust by specifying the factors placing the patient at risk for plantar fasciopathy. It seems intuitive to me that plantar fasciopathy secondary to sagittal plane deformities (e.g. equinus) will do fine no matter what you place under the patient's foot, since a heel lift is probably all they needed.
On the other hand, I believe heel pain with severe coronal plane deformities will benefit from an appropriately posted customized device. This paper, while limited in its methodology, hints that there may be some substance to this approach.
Nicholas A. Ciotola, DPM Methuen, MA